Vertebrate-specific glutaredoxin is essential for brain development.
Identifieur interne : 000898 ( Main/Exploration ); précédent : 000897; suivant : 000899Vertebrate-specific glutaredoxin is essential for brain development.
Auteurs : Lars Br Utigam [Suède] ; Lena Dorothee Schütte ; José Rodrigo Godoy ; Timour Prozorovski ; Manuela Gellert ; Giselbert Hauptmann ; Arne Holmgren ; Christopher Horst Lillig ; Carsten BerndtSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 1091-6490 ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Apoptose (MeSH), Axones (physiologie), Biologie du développement (MeSH), Danio zébré (embryologie), Encéphale (embryologie), Glutarédoxines (composition chimique), Glutarédoxines (génétique), Humains (MeSH), Lignée cellulaire tumorale (MeSH), Neurites (métabolisme), Oxydoréduction (MeSH), Protéines recombinantes (composition chimique), Régulation de l'expression des gènes au cours du développement (MeSH), Transduction du signal (MeSH), Vertébrés (MeSH).
- MESH :
- composition chimique : Glutarédoxines, Protéines recombinantes.
- embryologie : Danio zébré, Encéphale.
- génétique : Glutarédoxines.
- métabolisme : Neurites.
- physiologie : Axones.
- Animaux, Apoptose, Biologie du développement, Humains, Lignée cellulaire tumorale, Oxydoréduction, Régulation de l'expression des gènes au cours du développement, Transduction du signal, Vertébrés.
English descriptors
- KwdEn :
- Animals (MeSH), Apoptosis (MeSH), Axons (physiology), Brain (embryology), Cell Line, Tumor (MeSH), Developmental Biology (MeSH), Gene Expression Regulation, Developmental (MeSH), Glutaredoxins (chemistry), Glutaredoxins (genetics), Humans (MeSH), Neurites (metabolism), Oxidation-Reduction (MeSH), Recombinant Proteins (chemistry), Signal Transduction (MeSH), Vertebrates (MeSH), Zebrafish (embryology).
- MESH :
- chemical , chemistry : Glutaredoxins, Recombinant Proteins.
- embryology : Brain, Zebrafish.
- chemical , genetics : Glutaredoxins.
- metabolism : Neurites.
- physiology : Axons.
- Animals, Apoptosis, Cell Line, Tumor, Developmental Biology, Gene Expression Regulation, Developmental, Humans, Oxidation-Reduction, Signal Transduction, Vertebrates.
Abstract
Cellular functions and survival are dependent on a tightly controlled redox potential. Currently, an increasing amount of data supports the concept of local changes in the redox environment and specific redox signaling events controlling cell function. Specific protein thiol groups are the major targets of redox signaling and regulation. Thioredoxins and glutaredoxins catalyze reversible thiol-disulfide exchange reactions and are primary regulators of the protein thiol redox state. Here, we demonstrate that embryonic brain development depends on the enzymatic activity of glutaredoxin 2. Zebrafish with silenced expression of glutaredoxin 2 lost virtually all types of neurons by apoptotic cell death and the ability to develop an axonal scaffold. As demonstrated in zebrafish and in a human cellular model for neuronal differentiation, glutaredoxin 2 controls axonal outgrowth via thiol redox regulation of collapsin response mediator protein 2, a central component of the semaphorin pathway. This study provides an example of a specific thiol redox regulation essential for vertebrate embryonic development.
DOI: 10.1073/pnas.1110085108
PubMed: 22139372
PubMed Central: PMC3251147
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Currently, an increasing amount of data supports the concept of local changes in the redox environment and specific redox signaling events controlling cell function. Specific protein thiol groups are the major targets of redox signaling and regulation. Thioredoxins and glutaredoxins catalyze reversible thiol-disulfide exchange reactions and are primary regulators of the protein thiol redox state. Here, we demonstrate that embryonic brain development depends on the enzymatic activity of glutaredoxin 2. Zebrafish with silenced expression of glutaredoxin 2 lost virtually all types of neurons by apoptotic cell death and the ability to develop an axonal scaffold. As demonstrated in zebrafish and in a human cellular model for neuronal differentiation, glutaredoxin 2 controls axonal outgrowth via thiol redox regulation of collapsin response mediator protein 2, a central component of the semaphorin pathway. This study provides an example of a specific thiol redox regulation essential for vertebrate embryonic development.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22139372</PMID><DateCompleted><Year>2012</Year><Month>03</Month><Day>09</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1091-6490</ISSN><JournalIssue CitedMedium="Internet"><Volume>108</Volume><Issue>51</Issue><PubDate><Year>2011</Year><Month>Dec</Month><Day>20</Day></PubDate></JournalIssue><Title>Proceedings of the National Academy of Sciences of the United States of America</Title><ISOAbbreviation>Proc Natl Acad Sci U S A</ISOAbbreviation></Journal><ArticleTitle>Vertebrate-specific glutaredoxin is essential for brain development.</ArticleTitle><Pagination><MedlinePgn>20532-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1073/pnas.1110085108</ELocationID><Abstract><AbstractText>Cellular functions and survival are dependent on a tightly controlled redox potential. Currently, an increasing amount of data supports the concept of local changes in the redox environment and specific redox signaling events controlling cell function. Specific protein thiol groups are the major targets of redox signaling and regulation. Thioredoxins and glutaredoxins catalyze reversible thiol-disulfide exchange reactions and are primary regulators of the protein thiol redox state. Here, we demonstrate that embryonic brain development depends on the enzymatic activity of glutaredoxin 2. Zebrafish with silenced expression of glutaredoxin 2 lost virtually all types of neurons by apoptotic cell death and the ability to develop an axonal scaffold. As demonstrated in zebrafish and in a human cellular model for neuronal differentiation, glutaredoxin 2 controls axonal outgrowth via thiol redox regulation of collapsin response mediator protein 2, a central component of the semaphorin pathway. This study provides an example of a specific thiol redox regulation essential for vertebrate embryonic development.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bräutigam</LastName><ForeName>Lars</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles Väg 2, 17177 Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schütte</LastName><ForeName>Lena Dorothee</ForeName><Initials>LD</Initials></Author><Author ValidYN="Y"><LastName>Godoy</LastName><ForeName>José Rodrigo</ForeName><Initials>JR</Initials></Author><Author ValidYN="Y"><LastName>Prozorovski</LastName><ForeName>Timour</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Gellert</LastName><ForeName>Manuela</ForeName><Initials>M</Initials></Author><Author 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sort="Hauptmann, Giselbert" uniqKey="Hauptmann G" first="Giselbert" last="Hauptmann">Giselbert Hauptmann</name><name sortKey="Holmgren, Arne" sort="Holmgren, Arne" uniqKey="Holmgren A" first="Arne" last="Holmgren">Arne Holmgren</name><name sortKey="Lillig, Christopher Horst" sort="Lillig, Christopher Horst" uniqKey="Lillig C" first="Christopher Horst" last="Lillig">Christopher Horst Lillig</name><name sortKey="Prozorovski, Timour" sort="Prozorovski, Timour" uniqKey="Prozorovski T" first="Timour" last="Prozorovski">Timour Prozorovski</name><name sortKey="Schutte, Lena Dorothee" sort="Schutte, Lena Dorothee" uniqKey="Schutte L" first="Lena Dorothee" last="Schütte">Lena Dorothee Schütte</name></noCountry><country name="Suède"><region name="Svealand"><name sortKey="Br Utigam, Lars" sort="Br Utigam, Lars" uniqKey="Br Utigam L" first="Lars" last="Br Utigam">Lars Br Utigam</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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